Clinical Study Diffusion Tensor Histogram Analysis of Pediatric Diffuse Intrinsic Pontine Glioma

نویسندگان

  • Emilie A. Steffen-Smith
  • Joelle E. Sarlls
  • Carlo Pierpaoli
  • Joanna H. Shih
  • Robyn S. Bent
  • Katherine E. Warren
  • Roberta Rudà
چکیده

1 Pediatric Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Building 10, Room 1-5750, 9000 Rockville Pike, Bethesda, MD 20892, USA 2 In Vivo NMR Center, National Institute of Neurological Disorders and Stroke, National Institutes of the Health, Bethesda, MD 20892, USA 3 Program on Pediatric Imaging and Tissue Sciences, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA 4Biostatistics and Data Management Section, National Cancer Institute, Center for Cancer Research, National Institutes of the Health, Bethesda, MD 20892, USA 5 Center for Biomedical Engineering, School of Engineering, Brown University, Providence, RI 02912, USA

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Diffusion Tensor Histogram Analysis of Pediatric Diffuse Intrinsic Pontine Glioma

PURPOSE To evaluate tumor structure in children with diffuse intrinsic pontine glioma (DIPG) using histogram analyses of mean diffusivity (MD), determine potential treatment and corticosteroid-related effects on MD, and monitor changes in MD distributions over time. MATERIALS AND METHODS DTI was performed on a 1.5T GE scanner. Regions of interest included the entire FLAIR-defined tumor. MD da...

متن کامل

Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium.

BACKGROUND Diffuse intrinsic pontine glioma (DIPG) is associated with poor survival regardless of therapy. We used volumetric apparent diffusion coefficient (ADC) histogram metrics to determine associations with progression-free survival (PFS) and overall survival (OS) at baseline and after radiation therapy (RT). METHODS Baseline and post-RT quantitative ADC histograms were generated from fl...

متن کامل

Molecular insights into pediatric brain tumors have the potential to transform therapy.

High-throughput genomic technologies have shed light on the biologic heterogeneity of several pediatric brain tumors. The biology of the four common pediatric brain tumors-namely medulloblastoma; ependymoma; high-grade glioma (HGG), including diffuse intrinsic pontine glioma; and low-grade glioma-is highlighted in this CCR Focus article. The discovery that medulloblastoma consists of four diffe...

متن کامل

Measurable Supratentorial White Matter Volume Changes in Patients with Diffuse Intrinsic Pontine Glioma Treated with an Anti-Vascular Endothelial Growth Factor Agent, Steroids, and Radiation.

BACKGROUND AND PURPOSE Assessing the response to treatment in infiltrative brain tumors by using lesion volume-based response criteria is challenging. We hypothesized that in such tumors, volume measurements alone may not accurately capture changes in actual tumor burden during treatment. We longitudinally evaluated volume changes in both normal-appearing supratentorial white matter and the bra...

متن کامل

Parametric Response Mapping of Apparent Diffusion Coefficient (ADC) as an Imaging Biomarker to Distinguish Pseudoprogression from True Tumor Progression In Peptide- Based Vaccine Therapy for Pediatric Diffuse Instrinsic Pontine Glioma

Background and Purpose—Immune response to cancer therapy may result in pseudoprogression, which can only be identified retrospectively and which may disrupt an effective therapy. This study assesses whether serial parametric response mapping (PRM, a voxelby-voxel method of image analysis also known as functional diffusion mapping) analysis of ADC measurements following peptide-based vaccination...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014